Modular Oxime Formation by a trans‐AT Polyketide Synthase

• Published in: Angewandte Chemie Vol. 135; no. 34
• Main Authors: Minas, Hannah A., François, Romain M. M., Hemmerling, Franziska, Fraley, Amy E., Dieterich, Cora L., Rüdisser, Simon H., Meoded, Roy A., Collin, Sabrina, Weissman, Kira J., Gruez, Arnaud, Piel, Jörn
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 21.08.2023
• Subjects: Acyltransferase; Aldehydes; Assembly lines; Bacterial Natural Products; Biosynthesis; Catalysis; Chemistry; Crystal structure; Mutagenesis; Natural products; Oxime; Oxygenase; Polyketide synthase; Polyketides; Protein interaction; Proteins; X-Ray Crystallography

Modular trans‐acyltransferase polyketide synthases (trans‐AT PKSs) are enzymatic assembly lines that biosynthesize complex polyketide natural products. Relative to their better studied cis‐AT counterparts, the trans‐AT PKSs introduce remarkable chemical diversity into their polyketide products. A no...