Inside Cover: Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA‐Encoded Chemical Library (ChemBioChem 9/2017)

• Published in: Chembiochem : a European journal of chemical biology Vol. 18; no. 9; p. 826
• Main Authors: Cuozzo, John W., Centrella, Paolo A., Gikunju, Diana, Habeshian, Sevan, Hupp, Christopher D., Keefe, Anthony D., Sigel, Eric A., Soutter, Holly H., Thomson, Heather A., Zhang, Ying, Clark, Matthew A.
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 04.05.2017
• Subjects: Affinity; Bruton's tyrosine kinase; Coding; Deoxyribonucleic acid; DNA; DNA-encoded library; Inhibitors; kinase inhibitors; Libraries; small molecules; X-ray crystallography

The inside cover picture shows the discovery of a potent BTK inhibitor (orange) by affinity‐based selection from a DNA‐encoded library (top). Addition of ATP (beige) to the selection, which simulates the intracellular environment, displaced any low affinity compounds (purple) but could not displace...