O4.08 AGI5198, AN INHIBITOR OF IDH1R132H, PROTECTS IDH1R132H HCT116 CELLS AGAINST IRRADIATION

• Published in: Neuro-oncology (Charlottesville, Va.) Vol. 16; no. suppl 2; pp. ii8 - ii9
• Main Authors: Molenaar, R. J., Dimitrakopoulou, D., Stap, J., Bleeker, F. E., Van Noorden, C. J. F.
• Format: Journal Article
• Language: English
• Published: 01.09.2014
• Subjects: Adeno-associated virus

BACKGROUND: IDH1R132H mutations are both inaugural events in the formation of glioma and associated with prolonged glioma patient survival. The IDH1R132H mutation confers a neo-enzymatic function that results in accumulation of the oncometabolite D-2-hydroxyglutarate (D-2HG), which promotes gliomage...