Simplified Modular Access to Enantiopure 1,2-Aminoalcohols via Ni- Electrocatalytic Decarboxylative Arylation

• Published in: ChemRxiv
• Main Authors: Sun, Jiawei, Endo, Hirofumi, Emmanuel, Megan, Oderinde, Martins, Kawamata, Yu, baran, phil
• Format: Paper
• Language: English
• Published: Washington American Chemical Society 14.12.2023
• Edition: 1
• Subjects: Carboxylic acids; Chemistry; Functional groups; Organic Chemistry; Organic Synthesis and Reactions; Oxazolidine; Electrochemistry; Cross-Coupling; Nickel; Aminoalcohols; Stereoselective

Chiral aminoalcohols are omnipresent in bioactive compounds. Conventional strategies to access this motif involve multiple-step reactions to install requisite functionalities stere- oselectively using conventional polar bond analysis. This study re- veals that a simple chiral oxazolidine-based carbo...