Fas/S1P 1 crosstalk via NF-κB activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis

• Published in: Biochemical and biophysical research communications Vol. 490; no. 4; pp. 1274 - 1281
• Main Authors: Hutami, Islamy Rahma, Izawa, Takashi, Mino-Oka, Akiko, Shinohara, Takehiro, Mori, Hiroki, Iwasa, Akihiko, Tanaka, Eiji
• Format: Journal Article
• Language: English
• Published: United States 02.09.2017
• Subjects: Animals; Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - genetics; Arthritis, Rheumatoid - immunology; Arthritis, Rheumatoid - pathology; Autoimmunity; Bone Marrow Cells - drug effects; Bone Marrow Cells - immunology; Bone Marrow Cells - pathology; Bone Resorption - genetics; Bone Resorption - immunology; Bone Resorption - pathology; Bone Resorption - prevention & control; Cell Differentiation; Disease Models, Animal; fas Receptor - genetics; fas Receptor - immunology; Female; Gene Expression Regulation; Lysophospholipids - immunology; Macrophages - drug effects; Macrophages - immunology; Macrophages - pathology; Mice; Mice, Inbred MRL lpr; Mitogen-Activated Protein Kinases - genetics; Mitogen-Activated Protein Kinases - immunology; Neuropeptides - genetics; Neuropeptides - immunology; NF-kappa B - antagonists & inhibitors; NF-kappa B - genetics; NF-kappa B - immunology; Osteoclasts - drug effects; Osteoclasts - immunology; Osteoclasts - pathology; Osteogenesis - drug effects; Osteogenesis - immunology; Peptides - pharmacology; Phosphotransferases (Alcohol Group Acceptor) - genetics; Phosphotransferases (Alcohol Group Acceptor) - immunology; Primary Cell Culture; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - immunology; rac1 GTP-Binding Protein - genetics; rac1 GTP-Binding Protein - immunology; RANK Ligand - genetics; RANK Ligand - immunology; Receptors, Lysosphingolipid - genetics; Receptors, Lysosphingolipid - immunology; Signal Transduction; Sphingosine - analogs & derivatives; Sphingosine - immunology; Temporomandibular Joint - drug effects; Temporomandibular Joint - immunology; Temporomandibular Joint - pathology; SN50; Temporomandibular joint; Fas; Osteoclast; S1P

Enhanced turnover of subchondral trabecular bone is a hallmark of rheumatoid arthritis (RA) and it results from an imbalance between bone resorption and bone formation activities. To investigate the formation and activation of osteoclasts which mediate bone resorption, a Fas-deficient MRL/lpr mouse...