The SARS-CoV-2 M pro Dimer-Based Screening System: A Synthetic Biology Tool for Identifying Compounds with Dimerization Inhibitory Potential

• Published in: ACS synthetic biology Vol. 13; no. 2; pp. 509 - 520
• Main Authors: Giri-Rachman, Ernawati Arifin, Effendy, Vergio V, Azmi, Muhammad H S, Yamahoki, Nicholas, Stephanie, Rebecca, Agustiyanti, Dian F, Wisnuwardhani, Popi H, Angelina, Marissa, Rubiyana, Yana, Aditama, Reza, Ningrum, Ratih A, Wardiana, Andri, Fibriani, Azzania
• Format: Journal Article
• Language: English
• Published: United States 16.02.2024
• Subjects: COVID-19; dimer-based screening system; protease inhibitor; antivirus; drug discovery; main protease

The COVID-19 endemic remains a global concern. The search for effective antiviral candidates is still needed to reduce disease risk. However, the availability of high biosafety level laboratory facilities for drug screening is limited in number. To address this issue, a screening system that could b...