JAK2V617F阳性转CALR基因突变阳性血小板增多症一例
患者，男，63岁。主因＂间断头晕2个月＂于2009年5月6日首次入院。既往史：糖尿病20余年，应用中效胰岛素治疗；高血压病10余年，口服硝苯地平缓释片治疗，血压控制良好；多发性脑梗死2年，无后遗症。患者于入院前2个月前无明显诱因出现间断头晕、四肢麻木、乏力、记忆力下降、言语表达欠流利，就诊于保定市第一医院。查体：血压150/90 mmHg（1 mmHg=0.133 kPa），神清，周身浅表淋巴结未触及肿大，双肺呼吸音清，未闻及干湿啰音，心率82次/分，律齐，脾脏肋缘下2 cm，肝肋缘下未触及，双下肢无水肿。血常规：WBC 8.17×109/L，HGB 148 g/L，PLT 1 205×109...
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| Published in | Zhōnghuá xuèyèxué zázhì Vol. 38; no. 1; p. 38 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese English |
| Published |
No. 288, Nanjing road, Heping district, Tianjin
河北省人民医院血液内科, 石家庄,050000%承德医学院%保定市第一医院血液内科
2017
Editorial office of Chinese Journal of Hematology |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-2727 2707-9740 |
| DOI | 10.3760/cma.j.issn.0253-2727.2017.01.008 |
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| Abstract | 患者，男，63岁。主因＂间断头晕2个月＂于2009年5月6日首次入院。既往史：糖尿病20余年，应用中效胰岛素治疗；高血压病10余年，口服硝苯地平缓释片治疗，血压控制良好；多发性脑梗死2年，无后遗症。患者于入院前2个月前无明显诱因出现间断头晕、四肢麻木、乏力、记忆力下降、言语表达欠流利，就诊于保定市第一医院。查体：血压150/90 mmHg（1 mmHg=0.133 kPa），神清，周身浅表淋巴结未触及肿大，双肺呼吸音清，未闻及干湿啰音，心率82次/分，律齐，脾脏肋缘下2 cm，肝肋缘下未触及，双下肢无水肿。血常规：WBC 8.17×109/L，HGB 148 g/L，PLT 1 205×109/L。红细胞沉降率20 mm/1h，空腹血糖10.2 mmol/L；肝肾功能正常；抗核抗体谱正常；肿瘤标志物正常。头颅MRI：两侧丘脑、基底节、放射冠、脑干多发腔隙性脑梗死，部分软化灶形成，部分病灶新出现。 |
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| AbstractList | 患者，男，63岁。主因＂间断头晕2个月＂于2009年5月6日首次入院。既往史：糖尿病20余年，应用中效胰岛素治疗；高血压病10余年，口服硝苯地平缓释片治疗，血压控制良好；多发性脑梗死2年，无后遗症。患者于入院前2个月前无明显诱因出现间断头晕、四肢麻木、乏力、记忆力下降、言语表达欠流利，就诊于保定市第一医院。查体：血压150/90 mmHg（1 mmHg=0.133 kPa），神清，周身浅表淋巴结未触及肿大，双肺呼吸音清，未闻及干湿啰音，心率82次/分，律齐，脾脏肋缘下2 cm，肝肋缘下未触及，双下肢无水肿。血常规：WBC 8.17×109/L，HGB 148 g/L，PLT 1 205×109/L。红细胞沉降率20 mm/1h，空腹血糖10.2 mmol/L；肝肾功能正常；抗核抗体谱正常；肿瘤标志物正常。头颅MRI：两侧丘脑、基底节、放射冠、脑干多发腔隙性脑梗死，部分软化灶形成，部分病灶新出现。 |
| Author | 王素云 张丽军 刘晔璇 刘贵敏 付建珠 王凤云 谢旭磊 成志勇 |
| AuthorAffiliation | 河北省人民医院血液内科,石家庄050000 承德医学院 保定市第一医院血液内科 |
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| Author_FL | Wang Suyu Liu Guimin Cheng Zhiyong Xie Xulei Liu Yexuan Zhang Lijun Wang Fengyun Fu Jianzhu |
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| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. 2017年版权归中华医学会所有 Copyright © 2017 by Chinese Medical Association 2017 |
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| DocumentTitleAlternate | JAK2 V617F positive mutation transformed to calreticulin mutation in one patient with essential thrombocythemia |
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| Notes | 12-1090/R Wang Suyu, Zhang Lijun, Liu Yexuan, Liu Guimin, Fu Jianzhu, Wang Fengyun, Xie Xulei, Cheng Zhiyong （Cheng Zhiyong, Department of Hematology, The First Hospital of Baoding, Baoding 071000, China.） |
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| SubjectTerms | JAK2V617F 基因突变 多发性脑梗死 多发腔隙性脑梗死 病例报告 硝苯地平缓释片 胰岛素治疗 血小板增多症 阳性 |
| Title | JAK2V617F阳性转CALR基因突变阳性血小板增多症一例 |
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