18 F-Tetrafluoroborate, a PET Probe for Imaging Sodium/Iodide Symporter Expression: Whole-Body Biodistribution, Safety, and Radiation Dosimetry in Thyroid Cancer Patients

• Published in: Journal of Nuclear Medicine Vol. 58; no. 10; pp. 1666 - 1671
• Main Authors: O’Doherty, Jim, Jauregui-Osoro, Maite, Brothwood, Teresa, Szyszko, Teresa, Marsden, Paul K., O’Doherty, Michael J., Cook, Gary J.R., Blower, Philip J., Lewington, Val
• Format: Journal Article
• Language: English
• Published: United States 01.10.2017
• Subjects: Borates - adverse effects; Borates - metabolism; Borates - pharmacokinetics; Boric Acids - adverse effects; Boric Acids - metabolism; Boric Acids - pharmacokinetics; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Positron Emission Tomography Computed Tomography - methods; Radiometry; Safety; Symporters - metabolism; Thyroid Neoplasms - diagnostic imaging; Thyroid Neoplasms - metabolism; Tissue Distribution; 18F-TFB; thyroid imaging; PET/CT

We report the safety, biodistribution, and internal radiation dosimetry, in humans with thyroid cancer, of F-tetrafluoroborate ( F-TFB), a novel PET radioligand for imaging the human sodium/iodide symporter (hNIS). Serial whole-body PET scans of 5 subjects with recently diagnosed thyroid cancer were...