Effects of cholesterol depletion, pro‐inflammatory cytokines and the apolipoprotein E isoforms on ABCA7 protein levels in human neural cell lines and brain tissue

• Published in: Alzheimer's & dementia Vol. 19; no. S13
• Main Authors: Wiener, Joel P., Garliyev, Viktor, Desire, Sindy, Pratico, Anna, Serrano, Geidy E, Lyssenko, Nicholas N.
• Format: Journal Article
• Language: English
• Published: 01.12.2023

Background Strong evidence from diverse sources points to adenosine triphosphate‐binding cassette transporter subfamily A member 7 (ABCA7) as a major risk factor in Alzheimer’s disease (AD). However, the mode of its involvement with the disease and many aspects of its function are understood incompl...