64 Cu Treatment Planning and 67 Cu Therapy with Radiolabeled [ 64 Cu/ 67 Cu]MeCOSar-Octreotate in Subjects with Unresectable Multifocal Meningioma: Initial Results for Human Imaging, Safety, Biodistribution, and Radiation Dosimetry

• Published in: Journal of Nuclear Medicine Vol. 64; no. 5; pp. 704 - 710
• Main Authors: Bailey, Dale L., Willowson, Kathy P., Harris, Matthew, Biggin, Colin, Aslani, Alireza, Lengkeek, Nigel A., Stoner, Jon, Eslick, M. Enid, Marquis, Harry, Parker, Michelle, Roach, Paul J., Schembri, Geoffrey P.
• Format: Journal Article
• Language: English
• Published: United States 01.05.2023
• Subjects: Humans; Meningeal Neoplasms; Meningioma - diagnostic imaging; Meningioma - radiotherapy; Positron Emission Tomography Computed Tomography - methods; Radioisotopes; Radiometry; Radiopharmaceuticals - therapeutic use; Tissue Distribution; meningioma; copper radionuclides; theranostics; dosimetry; radionuclide therapy; safety

Our aim was to report the use of Cu and Cu as a theranostic pair of radionuclides in human subjects. An additional aim was to measure whole-organ dosimetry of Cu and Cu attached to the somatostatin analog octreotate using the sarcophagine MeCOSar chelator (SARTATE) in subjects with somatostatin rece...