Parametric Methods for Dynamic 11 C-Phenytoin PET Studies

• Published in: Journal of Nuclear Medicine Vol. 58; no. 3; pp. 479 - 483
• Main Authors: Mansor, Syahir, Yaqub, Maqsood, Boellaard, Ronald, Froklage, Femke E., de Vries, Anke, Bakker, Esther D.M., Voskuyl, Rob A., Eriksson, Jonas, Schwarte, Lothar A., Verbeek, Joost, Windhorst, Albert D., Lammertsma, Adriaan A.
• Format: Journal Article
• Language: English
• Published: United States 01.03.2017
• Subjects: Adult; ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism; Brain - diagnostic imaging; Brain - metabolism; Carbon Radioisotopes - blood; Carbon Radioisotopes - pharmacokinetics; Humans; Male; Metabolic Clearance Rate; Organ Specificity; Phenytoin - blood; Phenytoin - pharmacokinetics; Positron-Emission Tomography - methods; Radiopharmaceuticals - pharmacokinetics; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution; Young Adult; test-retest variability; parametric kinetic modeling; 11C-phenytoin; PET quantification

In this study, the performance of various methods for generating quantitative parametric images of dynamic C-phenytoin PET studies was evaluated. Double-baseline 60-min dynamic C-phenytoin PET studies, including online arterial sampling, were acquired for 6 healthy subjects. Parametric images were g...