First-in-Human Evaluation of 18 F-SynVesT-1, a Radioligand for PET Imaging of Synaptic Vesicle Glycoprotein 2A

• Published in: Journal of Nuclear Medicine Vol. 62; no. 4; pp. 561 - 567
• Main Authors: Naganawa, Mika, Li, Songye, Nabulsi, Nabeel, Henry, Shannan, Zheng, Ming-Qiang, Pracitto, Richard, Cai, Zhengxin, Gao, Hong, Kapinos, Michael, Labaree, David, Matuskey, David, Huang, Yiyun, Carson, Richard E.
• Format: Journal Article
• Language: English
• Published: United States 01.04.2021
• Subjects: Adult; Female; GPI-Linked Proteins - metabolism; Healthy Volunteers; Humans; Ligands; Male; Positron-Emission Tomography - adverse effects; Positron-Emission Tomography - methods; Pyridines - adverse effects; Pyridines - metabolism; Pyrrolidinones - adverse effects; Pyrrolidinones - metabolism; Safety; Synaptic Vesicles - metabolism; brain imaging; synaptic density; SV2A; PET; kinetic modeling

The use of synaptic vesicle glycoprotein 2A radiotracers with PET imaging could provide a way to measure synaptic density quantitatively in living humans. C-UCB-J (( )-1-((3-( C-methyl- C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one), previously developed and assessed in nonhuman p...