Smad7-Skp2 complex orchestrates c-Myc stability, impacting on the cytostatic effect of TGF-β

In most of human cancer, the c-Myc proto-oncogene is highly activated. Dysregulation of c-Myc oncoprotein contributes to drive tumorigenesis in numerous tissues and organs. Thus, targeting c-Myc stability can be a critical step for cancer therapy. Here we report Smad7 as a key molecule to regulate c...

Full description

Saved in:
Bibliographic Details
Published inJournal of cell science
Main Authors Kim, Tae-Aug, Kang, Jin Muk, Hyun, Ja-Shil, Lee, Bona, Kim, Staci Jakyong, Yang, Eun-Sung, Hong, Suntaek, Lee, Ho-Jae, Fujii, Makiko, Niederhuber, John E., Kim, Seong-Jin
Format Journal Article
LanguageEnglish
Published 01.01.2013
Online AccessGet full text

Cover

Abstract In most of human cancer, the c-Myc proto-oncogene is highly activated. Dysregulation of c-Myc oncoprotein contributes to drive tumorigenesis in numerous tissues and organs. Thus, targeting c-Myc stability can be a critical step for cancer therapy. Here we report Smad7 as a key molecule to regulate c-Myc stability and activity by recruiting F-box protein, Skp2. Ectopic expression of Smad7 down-regulated the protein level of c-Myc without affecting transcription level and significantly repressed its transcriptional activity, leading to inhibition of cell proliferation and tumorigenic activity. Furthermore, Smad7 enhanced ubiquitination of c-Myc through direct interaction with c-Myc and recruitment of Skp2. Ablation of Smad7 resulted in less sensitivity to the growth inhibitory effect of TGF-β by inducing stable c-Myc expression. In conclusion, these findings that Smad7 functions as a transductory role in c-Myc oncoprotein degradation and enhances the cytostatic effect of TGF-β signaling provide new insightful therapeutic approach for cancer treatment.
AbstractList In most of human cancer, the c-Myc proto-oncogene is highly activated. Dysregulation of c-Myc oncoprotein contributes to drive tumorigenesis in numerous tissues and organs. Thus, targeting c-Myc stability can be a critical step for cancer therapy. Here we report Smad7 as a key molecule to regulate c-Myc stability and activity by recruiting F-box protein, Skp2. Ectopic expression of Smad7 down-regulated the protein level of c-Myc without affecting transcription level and significantly repressed its transcriptional activity, leading to inhibition of cell proliferation and tumorigenic activity. Furthermore, Smad7 enhanced ubiquitination of c-Myc through direct interaction with c-Myc and recruitment of Skp2. Ablation of Smad7 resulted in less sensitivity to the growth inhibitory effect of TGF-β by inducing stable c-Myc expression. In conclusion, these findings that Smad7 functions as a transductory role in c-Myc oncoprotein degradation and enhances the cytostatic effect of TGF-β signaling provide new insightful therapeutic approach for cancer treatment.
Author Hong, Suntaek
Lee, Ho-Jae
Hyun, Ja-Shil
Lee, Bona
Kim, Staci Jakyong
Fujii, Makiko
Kim, Tae-Aug
Yang, Eun-Sung
Kang, Jin Muk
Niederhuber, John E.
Kim, Seong-Jin
Author_xml – sequence: 1
  givenname: Tae-Aug
  surname: Kim
  fullname: Kim, Tae-Aug
– sequence: 2
  givenname: Jin Muk
  surname: Kang
  fullname: Kang, Jin Muk
– sequence: 3
  givenname: Ja-Shil
  surname: Hyun
  fullname: Hyun, Ja-Shil
– sequence: 4
  givenname: Bona
  surname: Lee
  fullname: Lee, Bona
– sequence: 5
  givenname: Staci Jakyong
  surname: Kim
  fullname: Kim, Staci Jakyong
– sequence: 6
  givenname: Eun-Sung
  surname: Yang
  fullname: Yang, Eun-Sung
– sequence: 7
  givenname: Suntaek
  surname: Hong
  fullname: Hong, Suntaek
– sequence: 8
  givenname: Ho-Jae
  surname: Lee
  fullname: Lee, Ho-Jae
– sequence: 9
  givenname: Makiko
  surname: Fujii
  fullname: Fujii, Makiko
– sequence: 10
  givenname: John E.
  surname: Niederhuber
  fullname: Niederhuber, John E.
– sequence: 11
  givenname: Seong-Jin
  surname: Kim
  fullname: Kim, Seong-Jin
BookMark eNot0MFOAjEUheHGYCKgG5-ga2Px3rbQdmmIoAnGBbg0k9JpZZCZTqZdOK_lg_BMYnB1Fn9yFt-IDJrYeEJuESbIJX_YuzRBMQOuL8gQpVLMoFADMgTgyMxUiCsySmkPAIobNSQf69qWiq2_Wk5drNuD_6axczufcmezT9Sx197RlO22OlS5v6dV3VqXq-aTxobmnaeuz_HUc-WoD8G7TGOgm-WCHX-uyWWwh-Rv_ndM3hdPm_kzW70tX-aPK-YQuWYWtQWJQWqFMEXJeZA406UFLxS3xkjvS69mU6G52BoVEBGgFNq4soStFGNyd_51XUyp86Fou6q2XV8gFH8wxQmmOMOIX2QVV48
CitedBy_id crossref_primary_10_1007_s13277_014_2203_7
crossref_primary_10_1080_15384101_2016_1150393
crossref_primary_10_1101_cshperspect_a022095
crossref_primary_10_1016_j_bcp_2020_114155
crossref_primary_10_1002_jcb_25528
Cites_doi 10.1128/MCB.24.17.7524--7537.2004
10.1128/MCB.24.5.2083--2090.2004
10.1016/S0092--8674(02)00801--2
10.1016/S1097--2765(03)00193--X
10.1128/MCB.24.6.2546--2559.2004
10.1016/S0960--9822(00)00470--X
10.1152/physrev.00027.2001
10.1016/j.cub.2004.09.083
10.1128/MCB.24.6.2251--2262.2004
10.1038/35036504
10.1038/ncb1110
10.1182/blood.V95.6.2104
10.1128/MCB.25.9.3563--3574.2005
10.1074/jbc.M104170200
10.1038/sj.onc.1210686
10.1038/ncb2104
10.1074/jbc.M011019200
10.1038/sj.onc.1207259
10.1016/S1097-2765(05)00004-3
10.1074/jbc.C100008200
10.1172/JCI200112367
10.1073/pnas.081474898
10.1128/MCB.19.9.5913
10.1038/ncb1601
10.1146/annurev.cellbio.16.1.653
10.1128/MCB.01636--06
10.1111/j.1523--1755.2002.kid583.x
10.1038/ng0993--56
10.1101/gad.836800
10.1038/318237a0
10.1128/MCB.24.10.4241--4254.2004
10.1016/j.devcel.2006.06.014
10.1016/S1097--2765(00)00134--9
10.1016/j.semcdb.2005.02.010
10.1038/39369
10.1038/nature01119
10.1016/j.febslet.2005.12.034
10.1038/sj.emboj.7600217
10.1038/416703a
10.1016/S0959--440X(01)00266--4
10.1016/j.str.2012.07.014
10.1210/en.2011--1590
10.1093/emboj/cdg632
10.1038/onc.2012.18
10.1074/jbc.M002433200
10.1016/j.cell.2005.08.016
10.1016/S0016--5085(03)00666--8
10.1038/sj.onc.1204167
10.1016/S0092--8674(00)80303--7
10.1038/ni1451
10.1172/JCI12821
10.1158/0008--5472.CAN--04--2133
10.1073/pnas.0402770101
10.1016/S0065--230X(10)07006--5
10.1016/S1097--2765(00)80308--1
10.1016/S1097--2765(03)00173--4
ContentType Journal Article
DBID AAYXX
CITATION
DOI 10.1242/jcs.136028
DatabaseName CrossRef
DatabaseTitle CrossRef
DatabaseTitleList CrossRef
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1477-9137
ExternalDocumentID 10_1242_jcs_136028
GroupedDBID ---
-DZ
-~X
0R~
18M
2WC
34G
39C
4.4
53G
5GY
5RE
5VS
85S
AAYXX
ABDNZ
ABPPZ
ACGFO
ACGFS
ACIWK
ACNCT
ACPRK
ADBBV
ADCOW
AEILP
AENEX
AFFNX
AFRAH
AGGIJ
ALMA_UNASSIGNED_HOLDINGS
BAWUL
BTFSW
CITATION
CS3
DIK
DU5
E3Z
F5P
F9R
GX1
H13
HZ~
IH2
INIJC
KQ8
O9-
OK1
P2P
R.V
RCB
RHF
RHI
RNS
SJN
TN5
TR2
UPT
W2D
W8F
WH7
WOQ
YQT
~02
~KM
ID FETCH-LOGICAL-c1128-a18a041f4871051422f4168da0e372a994eede7653823b97f11100d389cdd0b43
ISSN 0021-9533
IngestDate Thu Sep 12 18:12:33 EDT 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c1128-a18a041f4871051422f4168da0e372a994eede7653823b97f11100d389cdd0b43
OpenAccessLink https://jcs.biologists.org/content/joces/127/2/411.full.pdf
ParticipantIDs crossref_primary_10_1242_jcs_136028
PublicationCentury 2000
PublicationDate 2013-01-01
PublicationDateYYYYMMDD 2013-01-01
PublicationDate_xml – month: 01
  year: 2013
  text: 2013-01-01
  day: 01
PublicationDecade 2010
PublicationTitle Journal of cell science
PublicationYear 2013
References Sicari (2021042613365062900_b47) 2012; 153
Chen (2021042613365062900_b7) 2002; 110
Hong (2021042613365062900_b18) 2007; 8
Warner (2021042613365062900_b49) 1999; 19
Liang (2021042613365062900_b32) 2004; 24
Kobe (2021042613365062900_b25) 2001; 11
Lasorella (2021042613365062900_b30) 2000; 407
Schiffer (2021042613365062900_b43) 2001; 108
von der Lehr (2021042613365062900_b48) 2003; 11
Hayashi (2021042613365062900_b17) 1997; 89
Kavsak (2021042613365062900_b21) 2000; 6
Nilsson (2021042613365062900_b37) 2004; 64
Yada (2021042613365062900_b52) 2004; 23
Albihn (2021042613365062900_b2) 2010; 107
Adhikary (2021042613365062900_b1) 2005; 123
Aragón (2021042613365062900_b3) 2012; 20
Glickman (2021042613365062900_b11) 2002; 82
Gstaiger (2021042613365062900_b13) 2001; 98
Yagi (2021042613365062900_b53) 2002; 277
Zhao (2021042613365062900_b56) 2000; 275
Kim (2021042613365062900_b23) 2004; 24
Kimura (2021042613365062900_b24) 2007; 31
Okado (2021042613365062900_b38) 2002; 62
Sears (2021042613365062900_b45) 2000; 14
Pulaski (2021042613365062900_b42) 2001; 276
Monteleone (2021042613365062900_b33) 2001; 108
Frederick (2021042613365062900_b10) 2004; 24
Kang (2021042613365062900_b20) 2012; 31
Kalra (2021042613365062900_b19) 2006; 580
Chen (2021042613365062900_b6) 2000; 6
Kowanetz (2021042613365062900_b27) 2004; 24
Sears (2021042613365062900_b44) 1999; 3
Welcker (2021042613365062900_b50) 2004; 14
Han (2021042613365062900_b14) 2004; 23
Seoane (2021042613365062900_b46) 2002; 419
Han (2021042613365062900_b16) 2008; 27
Nakao (2021042613365062900_b35) 1997; 389
Lallemand (2021042613365062900_b28) 2001; 20
Popov (2021042613365062900_b40) 2007; 9
Grandori (2021042613365062900_b12) 2000; 16
Nakayama (2021042613365062900_b36) 2005; 16
Kim (2021042613365062900_b22) 2003; 11
Yeh (2021042613365062900_b54) 2004; 6
Bahram (2021042613365062900_b4) 2000; 95
Papas (2021042613365062900_b39) 1985; 318
Bhatia (2021042613365062900_b5) 1993; 5
Koinuma (2021042613365062900_b26) 2003; 22
Han (2021042613365062900_b15) 2006; 11
Welcker (2021042613365062900_b51) 2004; 101
Zheng (2021042613365062900_b57) 2002; 416
Landström (2021042613365062900_b29) 2000; 10
Popov (2021042613365062900_b41) 2010; 12
Zhang (2021042613365062900_b55) 2007; 27
Murphy (2021042613365062900_b34) 2004; 24
Ebisawa (2021042613365062900_b9) 2001; 276
Dooley (2021042613365062900_b8) 2003; 125
Lasorella (2021042613365062900_b31) 2005; 25
References_xml – volume: 24
  start-page: 7524
  year: 2004
  ident: 2021042613365062900_b32
  article-title: Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2.
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.24.17.7524--7537.2004
  contributor:
    fullname: Liang
– volume: 24
  start-page: 2083
  year: 2004
  ident: 2021042613365062900_b34
  article-title: Id2 is dispensable for Myc-induced epidermal neoplasia.
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.24.5.2083--2090.2004
  contributor:
    fullname: Murphy
– volume: 110
  start-page: 19
  year: 2002
  ident: 2021042613365062900_b7
  article-title: E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression.
  publication-title: Cell
  doi: 10.1016/S0092--8674(02)00801--2
  contributor:
    fullname: Chen
– volume: 11
  start-page: 1189
  year: 2003
  ident: 2021042613365062900_b48
  article-title: The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription.
  publication-title: Mol. Cell
  doi: 10.1016/S1097--2765(03)00193--X
  contributor:
    fullname: von der Lehr
– volume: 24
  start-page: 2546
  year: 2004
  ident: 2021042613365062900_b10
  article-title: Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element.
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.24.6.2546--2559.2004
  contributor:
    fullname: Frederick
– volume: 10
  start-page: 535
  year: 2000
  ident: 2021042613365062900_b29
  article-title: Smad7 mediates apoptosis induced by transforming growth factor beta in prostatic carcinoma cells.
  publication-title: Curr. Biol.
  doi: 10.1016/S0960--9822(00)00470--X
  contributor:
    fullname: Landström
– volume: 82
  start-page: 373
  year: 2002
  ident: 2021042613365062900_b11
  article-title: The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00027.2001
  contributor:
    fullname: Glickman
– volume: 14
  start-page: 1852
  year: 2004
  ident: 2021042613365062900_b50
  article-title: A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size.
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2004.09.083
  contributor:
    fullname: Welcker
– volume: 24
  start-page: 2251
  year: 2004
  ident: 2021042613365062900_b23
  article-title: Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation.
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.24.6.2251--2262.2004
  contributor:
    fullname: Kim
– volume: 407
  start-page: 592
  year: 2000
  ident: 2021042613365062900_b30
  article-title: Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins.
  publication-title: Nature
  doi: 10.1038/35036504
  contributor:
    fullname: Lasorella
– volume: 6
  start-page: 308
  year: 2004
  ident: 2021042613365062900_b54
  article-title: A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells.
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1110
  contributor:
    fullname: Yeh
– volume: 95
  start-page: 2104
  year: 2000
  ident: 2021042613365062900_b4
  article-title: c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover.
  publication-title: Blood
  doi: 10.1182/blood.V95.6.2104
  contributor:
    fullname: Bahram
– volume: 31
  start-page: 829
  year: 2007
  ident: 2021042613365062900_b24
  article-title: MM-1 facilitates degradation of c-Myc by recruiting proteasome and a novel ubiquitin E3 ligase.
  publication-title: Int. J. Oncol.
  contributor:
    fullname: Kimura
– volume: 25
  start-page: 3563
  year: 2005
  ident: 2021042613365062900_b31
  article-title: Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice.
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.25.9.3563--3574.2005
  contributor:
    fullname: Lasorella
– volume: 277
  start-page: 854
  year: 2002
  ident: 2021042613365062900_b53
  article-title: c-myc is a downstream target of the Smad pathway.
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M104170200
  contributor:
    fullname: Yagi
– volume: 27
  start-page: 675
  year: 2008
  ident: 2021042613365062900_b16
  article-title: CEACAM5 and CEACAM6 are major target genes for Smad3-mediated TGF-beta signaling.
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1210686
  contributor:
    fullname: Han
– volume: 12
  start-page: 973
  year: 2010
  ident: 2021042613365062900_b41
  article-title: Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover.
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2104
  contributor:
    fullname: Popov
– volume: 276
  start-page: 14344
  year: 2001
  ident: 2021042613365062900_b42
  article-title: Phosphorylation of Smad7 at Ser-249 does not interfere with its inhibitory role in transforming growth factor-beta-dependent signaling but affects Smad7-dependent transcriptional activation.
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M011019200
  contributor:
    fullname: Pulaski
– volume: 23
  start-page: 1333
  year: 2004
  ident: 2021042613365062900_b14
  article-title: Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer.
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1207259
  contributor:
    fullname: Han
– volume: 6
  start-page: 127
  year: 2000
  ident: 2021042613365062900_b6
  article-title: Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7.
  publication-title: Mol. Cell
  doi: 10.1016/S1097-2765(05)00004-3
  contributor:
    fullname: Chen
– volume: 276
  start-page: 12477
  year: 2001
  ident: 2021042613365062900_b9
  article-title: Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation.
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.C100008200
  contributor:
    fullname: Ebisawa
– volume: 108
  start-page: 807
  year: 2001
  ident: 2021042613365062900_b43
  article-title: Apoptosis in podocytes induced by TGF-beta and Smad7.
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI200112367
  contributor:
    fullname: Schiffer
– volume: 98
  start-page: 5043
  year: 2001
  ident: 2021042613365062900_b13
  article-title: Skp2 is oncogenic and overexpressed in human cancers.
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.081474898
  contributor:
    fullname: Gstaiger
– volume: 19
  start-page: 5913
  year: 1999
  ident: 2021042613365062900_b49
  article-title: Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.19.9.5913
  contributor:
    fullname: Warner
– volume: 9
  start-page: 765
  year: 2007
  ident: 2021042613365062900_b40
  article-title: The ubiquitin-specific protease USP28 is required for MYC stability.
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1601
  contributor:
    fullname: Popov
– volume: 16
  start-page: 653
  year: 2000
  ident: 2021042613365062900_b12
  article-title: The Myc/Max/Mad network and the transcriptional control of cell behavior.
  publication-title: Annu. Rev. Cell Dev. Biol.
  doi: 10.1146/annurev.cellbio.16.1.653
  contributor:
    fullname: Grandori
– volume: 27
  start-page: 4488
  year: 2007
  ident: 2021042613365062900_b55
  article-title: Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation.
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.01636--06
  contributor:
    fullname: Zhang
– volume: 62
  start-page: 1178
  year: 2002
  ident: 2021042613365062900_b38
  article-title: Smad7 mediates transforming growth factor-beta-induced apoptosis in mesangial cells.
  publication-title: Kidney Int.
  doi: 10.1111/j.1523--1755.2002.kid583.x
  contributor:
    fullname: Okado
– volume: 5
  start-page: 56
  year: 1993
  ident: 2021042613365062900_b5
  article-title: Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas.
  publication-title: Nat. Genet.
  doi: 10.1038/ng0993--56
  contributor:
    fullname: Bhatia
– volume: 14
  start-page: 2501
  year: 2000
  ident: 2021042613365062900_b45
  article-title: Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.
  publication-title: Genes Dev.
  doi: 10.1101/gad.836800
  contributor:
    fullname: Sears
– volume: 318
  start-page: 237
  year: 1985
  ident: 2021042613365062900_b39
  article-title: Sequence curiosity in v-myc oncogene.
  publication-title: Nature
  doi: 10.1038/318237a0
  contributor:
    fullname: Papas
– volume: 24
  start-page: 4241
  year: 2004
  ident: 2021042613365062900_b27
  article-title: Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein.
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.24.10.4241--4254.2004
  contributor:
    fullname: Kowanetz
– volume: 11
  start-page: 301
  year: 2006
  ident: 2021042613365062900_b15
  article-title: Smad7-induced beta-catenin degradation alters epidermal appendage development.
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2006.06.014
  contributor:
    fullname: Han
– volume: 6
  start-page: 1365
  year: 2000
  ident: 2021042613365062900_b21
  article-title: Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.
  publication-title: Mol. Cell
  doi: 10.1016/S1097--2765(00)00134--9
  contributor:
    fullname: Kavsak
– volume: 16
  start-page: 323
  year: 2005
  ident: 2021042613365062900_b36
  article-title: Regulation of the cell cycle by SCF-type ubiquitin ligases.
  publication-title: Semin. Cell Dev. Biol.
  doi: 10.1016/j.semcdb.2005.02.010
  contributor:
    fullname: Nakayama
– volume: 389
  start-page: 631
  year: 1997
  ident: 2021042613365062900_b35
  article-title: Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.
  publication-title: Nature
  doi: 10.1038/39369
  contributor:
    fullname: Nakao
– volume: 419
  start-page: 729
  year: 2002
  ident: 2021042613365062900_b46
  article-title: Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage.
  publication-title: Nature
  doi: 10.1038/nature01119
  contributor:
    fullname: Seoane
– volume: 580
  start-page: 431
  year: 2006
  ident: 2021042613365062900_b19
  article-title: The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-Myc.
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2005.12.034
  contributor:
    fullname: Kalra
– volume: 23
  start-page: 2116
  year: 2004
  ident: 2021042613365062900_b52
  article-title: Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7600217
  contributor:
    fullname: Yada
– volume: 416
  start-page: 703
  year: 2002
  ident: 2021042613365062900_b57
  article-title: Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
  publication-title: Nature
  doi: 10.1038/416703a
  contributor:
    fullname: Zheng
– volume: 11
  start-page: 725
  year: 2001
  ident: 2021042613365062900_b25
  article-title: The leucine-rich repeat as a protein recognition motif.
  publication-title: Curr. Opin. Struct. Biol.
  doi: 10.1016/S0959--440X(01)00266--4
  contributor:
    fullname: Kobe
– volume: 20
  start-page: 1726
  year: 2012
  ident: 2021042613365062900_b3
  article-title: Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways.
  publication-title: Structure
  doi: 10.1016/j.str.2012.07.014
  contributor:
    fullname: Aragón
– volume: 153
  start-page: 861
  year: 2012
  ident: 2021042613365062900_b47
  article-title: c-myc and skp2 coordinate p27 degradation, vascular smooth muscle proliferation, and neointima formation induced by the parathyroid hormone-related protein.
  publication-title: Endocrinology
  doi: 10.1210/en.2011--1590
  contributor:
    fullname: Sicari
– volume: 22
  start-page: 6458
  year: 2003
  ident: 2021042613365062900_b26
  article-title: Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7.
  publication-title: EMBO J.
  doi: 10.1093/emboj/cdg632
  contributor:
    fullname: Koinuma
– volume: 31
  start-page: 5123
  year: 2012
  ident: 2021042613365062900_b20
  article-title: CBL enhances breast tumor formation by inhibiting tumor suppressive activity of TGF-β signaling.
  publication-title: Oncogene
  doi: 10.1038/onc.2012.18
  contributor:
    fullname: Kang
– volume: 275
  start-page: 23992
  year: 2000
  ident: 2021042613365062900_b56
  article-title: Smad7 and Smad6 differentially modulate transforming growth factor beta -induced inhibition of embryonic lung morphogenesis.
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M002433200
  contributor:
    fullname: Zhao
– volume: 123
  start-page: 409
  year: 2005
  ident: 2021042613365062900_b1
  article-title: The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation.
  publication-title: Cell
  doi: 10.1016/j.cell.2005.08.016
  contributor:
    fullname: Adhikary
– volume: 125
  start-page: 178
  year: 2003
  ident: 2021042613365062900_b8
  article-title: Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats.
  publication-title: Gastroenterology
  doi: 10.1016/S0016--5085(03)00666--8
  contributor:
    fullname: Dooley
– volume: 20
  start-page: 879
  year: 2001
  ident: 2021042613365062900_b28
  article-title: Smad7 inhibits the survival nuclear factor kappaB and potentiates apoptosis in epithelial cells.
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1204167
  contributor:
    fullname: Lallemand
– volume: 89
  start-page: 1165
  year: 1997
  ident: 2021042613365062900_b17
  article-title: The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling.
  publication-title: Cell
  doi: 10.1016/S0092--8674(00)80303--7
  contributor:
    fullname: Hayashi
– volume: 8
  start-page: 504
  year: 2007
  ident: 2021042613365062900_b18
  article-title: Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2.
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1451
  contributor:
    fullname: Hong
– volume: 108
  start-page: 601
  year: 2001
  ident: 2021042613365062900_b33
  article-title: Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease.
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI12821
  contributor:
    fullname: Monteleone
– volume: 64
  start-page: 7296
  year: 2004
  ident: 2021042613365062900_b37
  article-title: Id2 is dispensable for myc-induced lymphomagenesis.
  publication-title: Cancer Res.
  doi: 10.1158/0008--5472.CAN--04--2133
  contributor:
    fullname: Nilsson
– volume: 101
  start-page: 9085
  year: 2004
  ident: 2021042613365062900_b51
  article-title: The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation.
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0402770101
  contributor:
    fullname: Welcker
– volume: 107
  start-page: 163
  year: 2010
  ident: 2021042613365062900_b2
  article-title: MYC in oncogenesis and as a target for cancer therapies.
  publication-title: Adv. Cancer Res.
  doi: 10.1016/S0065--230X(10)07006--5
  contributor:
    fullname: Albihn
– volume: 3
  start-page: 169
  year: 1999
  ident: 2021042613365062900_b44
  article-title: Ras enhances Myc protein stability.
  publication-title: Mol. Cell
  doi: 10.1016/S1097--2765(00)80308--1
  contributor:
    fullname: Sears
– volume: 11
  start-page: 1177
  year: 2003
  ident: 2021042613365062900_b22
  article-title: Skp2 regulates Myc protein stability and activity.
  publication-title: Mol. Cell
  doi: 10.1016/S1097--2765(03)00173--4
  contributor:
    fullname: Kim
SSID ssj0007297
Score 2.0975037
Snippet In most of human cancer, the c-Myc proto-oncogene is highly activated. Dysregulation of c-Myc oncoprotein contributes to drive tumorigenesis in numerous...
SourceID crossref
SourceType Aggregation Database
Title Smad7-Skp2 complex orchestrates c-Myc stability, impacting on the cytostatic effect of TGF-β
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bT9swFLZY0aS9IC5D4ypLjKfOIxcnaR6hlBVQ99Ii8TJVtuNAhUiqXiTKz-KH8Js4J3aTbgyJ7SWKrDiJ_CX2d47Pdw4hXyXqtpTEP015YKCEKYs15yxMXBlI4fs-R3Fy52fYvuIX18F1VW20UJdM5Hf1-Fddyf-gCm2AK6pk_wHZ8qbQAOeALxwBYTi-C-PuvUgi1r0beiY0XD_U81FRAQsTQIzrinVmCr0FRQRsMZxGFVmEOpsARzWb5KgqGigb24H0sffjjB02W4cn3hvkFf39dbt6Vtv4xbfVE5odT2_KVuuQvhhk9c601AW1Z1OjChGse1uFedi4oJPcFPWe-yOwNkTpj5jrA1zcFDbTljbTKseNYtekd3k1aQNLwElbjTHmzrFa8d8yY_-xYpVxhGjBQO8-9O2bvh_IshfFAZrhp-eX5ZoMJoQt3mvezSaqhb5H1XMXqMkCx-itkhU7vvTYIL1GlnS2Tj6acqGzDfKrwptavOki3rTAm5Z4f6Ml2jTPKKBNK7SpQZvmKUW0n58-k6uzVq_ZZrY8BlNAkhtMuA3hcDcFk9PFLPaelwK7biTC0X7kiTjmwH90FAa41SvjKHUxPWACDFUliSO5v0lqWZ7pL4SG8PZgWAodNhzOlQIO6YOhAKZkEMvYcbbIwXxk-kOTBaX_euy333XVDvlUfTa7pDYZTfUeELuJ3C8wewHq5kpW
link.rule.ids 315,786,790,27957,27958
linkProvider Flying Publisher
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Smad7-Skp2+complex+orchestrates+c-Myc+stability%2C+impacting+on+the+cytostatic+effect+of+TGF-%CE%B2&rft.jtitle=Journal+of+cell+science&rft.au=Kim%2C+Tae-Aug&rft.au=Kang%2C+Jin+Muk&rft.au=Hyun%2C+Ja-Shil&rft.au=Lee%2C+Bona&rft.date=2013-01-01&rft.issn=0021-9533&rft.eissn=1477-9137&rft_id=info:doi/10.1242%2Fjcs.136028&rft.externalDBID=n%2Fa&rft.externalDocID=10_1242_jcs_136028
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9533&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9533&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9533&client=summon