Local Treg Immunomodulation Cures Metastatic Lymphoma Including CNS Sites

• Published in: Blood Vol. 118; no. 21; p. LBA-2
• Main Authors: Marabelle, Aurelien, Kohrt, Holbrook E, Brody, Joshua, Torchia, James Anthony, Zhou, Gang, Luong, Richard, Rajapaksa, Ranjani, Tse, Victor, Levy, Ronald
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 18.11.2011

Abstract LBA-2 CD4+CD25+FOXP3+ regulatory T-cells (Tregs) protect cancers from the immune system. They express important functional molecules such as CTLA-4 and Ox40 on their surface. Anti-CTLA4 monoclonal antibody (mAb) is the first drug to improve survival of refractory metastatic melanoma. Its re...