The curcumin analog, GO-Y022 suppressed the pressure overload-induced systolic dysfunction at a lower concentration than curcumin

• Published in: Proceedings for Annual Meeting of The Japanese Pharmacological Society Vol. 95; p. 1-SS-34
• Main Authors: Yuta, Hirako, Shimizu, Kana, Funamoto, Masahumi, Kawase, Yuto, Wu, Hanhao, Sunagawa, Yoichi, Katanasaka, Yasuhumi, Shimizu, Satoshi, Shibata, Hiroyuki, Hasegawa, Koji, Morimoto, Tatsuya
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Pharmacological Society 2022

Background: We previously reported that natural compound curcumin suppresses cardiomyocyte hypertrophy and the development of heart failure via inhibiting p300 histone acetyltransferase (HAT) activity. In this study, we investigated the effect of curcumin analogue, GO-Y022 on p300-HAT activity, cult...