Cardio Protective Effect of Solanum nigrum Linn. in Isoproterenol Induced Myocardial Infarction in Rat

• Published in: Science, technology and arts research Vol. 4; no. 4; pp. 77 - 82
• Main Authors: Shaik, Sameer Amjad, Huded, Shivaprasad, Fathima, Asra, Preran, K.H., Fathima, Syeda Juveriya, Khanum, Farhath
• Format: Journal Article
• Language: English
• Published: Nekemete Wollega University 14.10.2016
• Subjects: Alzheimer's disease; Ancient languages; Animals; Ayurvedic medicine; Body weight; Cardiovascular disease; Cholesterol; Diabetes; Drug dosages; Echocardiography; EKG; Enzymes; Fatalities; Heart; Heart attacks; Herbal medicine; Hypertension; In vivo methods and tests; Industrialized nations; Isoproterenol; Medicinal plants; Metabolic disorders; Morbidity; Mortality; Myocardial infarction; Parameter estimation; Solanum nigrum; Triglycerides; India
• DOI: 10.4314/star.v4i4.11
• ISSN: 2226-7522

Myocardial infarction is one of the highest confronting metabolic syndromes which cause morbidity and mortality across the world. Recently, the renewed interests in medicinal plants have certain preventive action in treatment of cardiovascular disorder. The aim of the study was to investigate the cardio protective effects of Solanum nigrum Linn (hydro alcoholic extract) in isoproterenol induced myocardial infarction. The extracts were investigated for in vivo cardio protective activity; the rats were pre treated with hydro alcoholic extract (75mg, 150mg and 300mg) for a period of 21 days. Standard drug (carvedilol - 2mg/kg) was used to compare the results with various parameters like bodyweight, ECG, heart weight, serum parameters and enzyme estimation. The rats fed with extracts showed dose dependent cardio protective activity. Isoproterenol treated animals showed a marked increase in serum marker enzymes such as CK-MB, LDH, cholesterol, triglycerides, SGOT, SGPT. It was also observed that there was substantial increase in heart and body weight along with endogenous enzyme levels of LPO. There was significant decrease in levels of SOD, CAT and GSH. Treatment group significantly reduced the effects of isoproterenol induced myocardial infarction. Solanum nigrum hydro alcoholic extract treated groups possess cardio protective effect against isoproterenol induced myocardial infarction.