Self-Reinforced Bimetallic Mito-Jammer for Ca 2+ Overload-Mediated Cascade Mitochondrial Damage for Cancer Cuproptosis Sensitization

• Published in: Advanced science Vol. 11; no. 15; p. e2306031
• Main Authors: Du, Chier, Guo, Xun, Qiu, Xiaoling, Jiang, Weixi, Wang, Xiaoting, An, Hongjin, Wang, Jingxue, Luo, Yuanli, Du, Qianying, Wang, Ruoyao, Cheng, Chen, Guo, Yuan, Teng, Hua, Ran, Haitao, Wang, Zhigang, Li, Pan, Zhou, Zhiyi, Ren, Jianli
• Format: Journal Article
• Language: English
• Published: Germany 01.04.2024
• Subjects: Adenosine Triphosphate; Cell Death; Humans; Hydrogen Peroxide; Mitomycin; Neoplasms; Reactive Oxygen Species; Tumor Microenvironment; cascade mitochondria damage; cuproptosis; chemodynamic therapy; Ca2+ overload; immunotherapy

Overproduction of reactive oxygen species (ROS), metal ion accumulation, and tricarboxylic acid cycle collapse are crucial factors in mitochondria-mediated cell death. However, the highly adaptive nature and damage-repair capabilities of malignant tumors strongly limit the efficacy of treatments bas...