Ultralow Ru Single Atoms Confined in Cerium Oxide Nanoglues for Highly-Sensitive and Robust H 2 O 2 -Related Biocatalytic Diagnosis
Exploring highly efficient, portable, and robust biocatalysts is a great challenge in colorimetric biosensors. To overcome the challenging states in creating single-atom biocatalysts, such as insufficient activity and stability, here, this work has engineered a unique CeO support as nanoglue to tigh...
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| Published in | Small (Weinheim an der Bergstrasse, Germany) Vol. 19; no. 52; p. e2304532 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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01.12.2023
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| Abstract | Exploring highly efficient, portable, and robust biocatalysts is a great challenge in colorimetric biosensors. To overcome the challenging states in creating single-atom biocatalysts, such as insufficient activity and stability, here, this work has engineered a unique CeO
support as nanoglue to tightly anchor the Ru single-atom sites (CeO
-Ru) with strong electronic coupling for achieving highly sensitive and robust H
O
-related biocatalytic diagnosis. The morphology and chemical/electronic structure analysis demonstrates that the Ru atoms are well-dispersed on CeO
surface to form high-density active sites. Benefiting from the unique structure, the prepared CeO
-Ru exhibits outstanding peroxidase (POD) like catalytic activity and selectivity to H
O
. Steady-state kinetic study results show that the CeO
-Ru presents the highest V
and turnover number than the state-of-the-art POD-like biocatalysts. Consequently, the CeO
-Ru discloses a high efficiency, good selectivity, and robust stability in the colorimetric detection of L-cysteine, glucose, and uric acid. Notably, the limit of detection (LOD) can reach 0.176 × 10
m for the L-cysteine, 0.095 × 10
m for the glucose, and 0.088 × 10
m for the uric acid via cascade reaction. This work suggests that the proposed unique CeO
nanoglue will offer a new path to create single-atom noble metal biocatalysts and take a step closer to future biotherapeutic and biocatalytic applications. |
|---|---|
| AbstractList | Abstract
Exploring highly efficient, portable, and robust biocatalysts is a great challenge in colorimetric biosensors. To overcome the challenging states in creating single‐atom biocatalysts, such as insufficient activity and stability, here, this work has engineered a unique CeO
2
support as nanoglue to tightly anchor the Ru single‐atom sites (CeO
2
‐Ru) with strong electronic coupling for achieving highly sensitive and robust H
2
O
2
‐related biocatalytic diagnosis. The morphology and chemical/electronic structure analysis demonstrates that the Ru atoms are well‐dispersed on CeO
2
surface to form high‐density active sites. Benefiting from the unique structure, the prepared CeO
2
‐Ru exhibits outstanding peroxidase (POD) like catalytic activity and selectivity to H
2
O
2
. Steady‐state kinetic study results show that the CeO
2
‐Ru presents the highest
V
max
and turnover number than the state‐of‐the‐art POD‐like biocatalysts. Consequently, the CeO
2
‐Ru discloses a high efficiency, good selectivity, and robust stability in the colorimetric detection of
L
‐cysteine, glucose, and uric acid. Notably, the limit of detection (LOD) can reach 0.176 × 10
−3
m
for the
L
‐cysteine, 0.095 × 10
−3
m
for the glucose, and 0.088 × 10
−3
m
for the uric acid via cascade reaction. This work suggests that the proposed unique CeO
2
nanoglue will offer a new path to create single‐atom noble metal biocatalysts and take a step closer to future biotherapeutic and biocatalytic applications. Exploring highly efficient, portable, and robust biocatalysts is a great challenge in colorimetric biosensors. To overcome the challenging states in creating single-atom biocatalysts, such as insufficient activity and stability, here, this work has engineered a unique CeO support as nanoglue to tightly anchor the Ru single-atom sites (CeO -Ru) with strong electronic coupling for achieving highly sensitive and robust H O -related biocatalytic diagnosis. The morphology and chemical/electronic structure analysis demonstrates that the Ru atoms are well-dispersed on CeO surface to form high-density active sites. Benefiting from the unique structure, the prepared CeO -Ru exhibits outstanding peroxidase (POD) like catalytic activity and selectivity to H O . Steady-state kinetic study results show that the CeO -Ru presents the highest V and turnover number than the state-of-the-art POD-like biocatalysts. Consequently, the CeO -Ru discloses a high efficiency, good selectivity, and robust stability in the colorimetric detection of L-cysteine, glucose, and uric acid. Notably, the limit of detection (LOD) can reach 0.176 × 10 m for the L-cysteine, 0.095 × 10 m for the glucose, and 0.088 × 10 m for the uric acid via cascade reaction. This work suggests that the proposed unique CeO nanoglue will offer a new path to create single-atom noble metal biocatalysts and take a step closer to future biotherapeutic and biocatalytic applications. |
| Author | Li, Qian Zhu, Huang Yuan, Minjia Wang, Mao Zhou, Mi Luo, Xianglin Gao, Yang Cheng, Chong Wu, Zihe |
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| Keywords | cerium oxide biosensors peroxidase-mimetics biocatalytic diagnosis single atom catalysts |
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| Title | Ultralow Ru Single Atoms Confined in Cerium Oxide Nanoglues for Highly-Sensitive and Robust H 2 O 2 -Related Biocatalytic Diagnosis |
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