Imine Directed CpRh III -Catalyzed N-H Functionalization and Annulation with Amino Amides, Aldehydes, and Diazo Compounds

• Published in: Angewandte Chemie International Edition Vol. 62; no. 1; p. e202210822
• Main Authors: Zoll, Adam J, Molas, Jenna C, Mercado, Brandon Q, Ellman, Jonathan A
• Format: Journal Article
• Language: English
• Published: Germany 02.01.2023
• Subjects: Aldehydes - chemistry; Amides; Azo Compounds; Catalysis; Imines; Rhodium - chemistry; Heterocycles; Multicomponent Reactions; Imine; N−H Functionalization; Rhodium

A multicomponent annulation that proceeds by imine directed Cp*Rh -catalyzed N-H functionalization is disclosed. The transformation affords piperazinones displaying a range of functionality and is the first example of transition metal-catalyzed multicomponent N-H functionalization. A broad range of...