eHydrogenation: Hydrogen‐free Electrochemical Hydrogenation

Abstract Hydrogenation reactions are staple transformations commonly used across scientific fields to synthesise pharmaceuticals, natural products, and various functional materials. However, the vast majority of these reactions require the use of a toxic and costly catalyst leading to unpractical, h...

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Bibliographic Details
Published inAngewandte Chemie Vol. 135; no. 38
Main Authors Russo, Camilla, Leech, Matthew C., Walsh, Jamie M., Higham, Joe I., Giannessi, Lisa, Lambert, Emmanuelle, Kiaku, Cyrille, Poole, Darren L., Mason, Joseph, Goodall, Charles A. I., Devo, Perry, Giustiniano, Mariateresa, Radi, Marco, Lam, Kevin
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 18.09.2023
Subjects
Alkynes
Catalysts
Chemical reactions
Chemistry
Deuterium
Electrochemistry
Functional materials
Hydrogenation
Labeling
Natural products
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Summary:Abstract Hydrogenation reactions are staple transformations commonly used across scientific fields to synthesise pharmaceuticals, natural products, and various functional materials. However, the vast majority of these reactions require the use of a toxic and costly catalyst leading to unpractical, hazardous and often functionally limited conditions. Herein, we report a new, general, practical, efficient, mild and high‐yielding hydrogen‐free electrochemical method for the reduction of alkene, alkyne, nitro and azido groups. Finally, this method has been applied to deuterium labelling.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.202309563