Role of endothelin-1 and its receptors, ET A and ET B , in the survival of human vascular endothelial cells

• Published in: Canadian journal of physiology and pharmacology Vol. 95; no. 10; pp. 1298 - 1305
• Main Authors: Mikhail, Marianne, Vachon, Pierre H., D’Orléans-Juste, Pedro, Jacques, Danielle, Bkaily, Ghassan
• Format: Journal Article
• Language: English
• Published: Canada 01.10.2017
• Subjects: Apoptosis - drug effects; Caspase 3 - metabolism; Cell Survival - drug effects; Cells, Cultured; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Endothelial Cells - pathology; Endothelin A Receptor Antagonists - pharmacology; Endothelin B Receptor Antagonists - pharmacology; Endothelin-1 - pharmacology; Genistein - toxicity; Humans; Receptor, Endothelin A - agonists; Receptor, Endothelin A - metabolism; Receptor, Endothelin B - agonists; Receptor, Endothelin B - metabolism; Signal Transduction - drug effects; ETB receptor; human vascular endothelial cells; ETA receptor; cellules endothéliales vasculaires humaines; récepteur ETB; apoptosis; récepteur ETA; endothéline-1; apoptose; endothelin-1

Our previous work showed the presence of endothelin-1 (ET-1) receptors, ET A and ET B , in human vascular endothelial cells (hVECs). In this study, we wanted to verify whether ET-1 plays a role in the survival of hVECs via the activation of its receptors ET A and (or) ET B (ET A R and ET B R, respec...