Anti-Tumor Responses By Ibrutinib and Anti-PD-1 Blockade Is Enhanced By Phosphatidylserine-Targeting Antibody Therapy

• Published in: Blood Vol. 128; no. 22; p. 5379
• Main Authors: Gong, Jian, Gray, Michael, Hutchins, Jeff, Freimark, Bruce
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 02.12.2016

Introduction: Phosphatidylserine (PS) is a phospholipid normally residing in the inner leaflet of the plasma membrane that becomes exposed on vascular endothelial cells and tumor cells in the tumor microenvironment, particularly in response to chemotherapy and irradiation. Binding of antibodies targ...