Array-Based Comparative Genomic Hybridization (Array-CGH) in Multiple Myeloma (MM) and Plasma Cell Leukemia (PCL): Recurrent Imbalances within a Highly Heterogeneous Background of Genomic Disruption

• Published in: Blood Vol. 106; no. 11; p. 5088
• Main Authors: Drandi, Daniela, Ladetto, Marco, Vallet, Sonia, Santo, Loredana, Ricca, Irene, Dell'Aquila, Maria, Monitillo, Luigia, Astolfi, Monica, Ruggeri, Marina, Ambrosini, Maria Teresa, De Marco, Federica, Marino, Lydia, Mantoan, Barbara, Pagliano, Gloria, Omedè, Paola, Palumbo, Antonio, Boccadoro, Mario
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 16.11.2005

Introduction: array-CGH is significantly impacting on cancer cytogenetic. We used this technique to perform pan-genomic screening in 15 patients with MM and 4 with de novo PCL. Patients and methods. Bone marrow samples were employed. If tumor contamination was below 20% plasma cells were purified wi...