Interleukin-7 Over-Expression Regulates T Cell Versus B Cell Lineage Development in the Thymus

• Published in: Blood Vol. 104; no. 11; p. 3238
• Main Authors: El Kassar, Nahed, Lucas, Philip J., Flomerfelt, Frank, Merchant, Melinda, Bare, Catherine V., Mahmud, Semhar, Mackall, Crystal L., Bhandoola, Avinash, Gress, Ronald E.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 16.11.2004

We have shown that high IL-7 transgene (Tg) over-expression (39-fold at day 1 in thymic tissue) under the T cell specific, proximal lck promoter had a dose effect on TCRαβ that was accompanied by active B cell development in the thymus. To further characterize these affects in the thymus of IL-7 tra...