Quantitative Analysis of Angiogenesis Inhibition by Cleaved High Molecular Weight Kininogen Using VESGEN

• Published in: Blood Vol. 110; no. 11; p. 3907
• Main Authors: Ribita, Daniela, Zlotoff, Benjamin, McKay, Terri L., Gedeon, Daniel J., Hylton, Alan G., Rasin, Arkady, McCrae, Keith R., Parsons-Wingerter, Patricia
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 16.11.2007

Angiogenesis requires specific molecular regulation of complex vascular branching morphology. The cleaved form of high molecular weight kininogen (HKa) has been shown to cause apoptosis of proliferating endothelial cells, and inhibit angiogenesis in vivo. However, critical morphological effects of H...