204-LB: The In Vitro Characteristics of Human Islet Cells from Diverse Donors, Coaggregated with Human Mesenchymal Stromal Cells to form “Neo-islets”, Are Consistently Identical: Relevance to Clinical Trials in Diabetic Subjects

• Published in: Diabetes (New York, N.Y.) Vol. 69; no. Supplement_1
• Main Authors: GOOCH, ANNA, CHOWDHURY, SABIHA S., ZHANG, PING, HU, ZHUMA, WESTENFELDER, CHRISTOF
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.06.2020
• Subjects: Blood glucose; Cell culture; Clinical trials; Demography; Diabetes; Diabetes mellitus; Gene expression; Growth rate; Immune response; Immunosuppressive agents; Insulin; Islet cells; Mesenchymal stem cells; Mesenchyme; Organoids; Pets; Stromal cells

We reported that allogeneic “Neo-Islets” (NIs), organoids composed of ~ equal numbers of Mesenchymal Stromal Cells and culture expanded Islet Cells (ICs) do, when given i.p., omentally engraft and permanently restore euglycemia in auto-immune diabetic NOD mice, i.e., without the use of either encaps...