Angiogenic Factors eNOS and VEGF Have Increased Expression in Granulocytes of JAK2V617F Homozygous Forms of Polycythemia Vera

• Published in: Blood Vol. 118; no. 21; p. 3847
• Main Authors: Cokic, Vladan P, Markovic, Dragana, Mitrovic, Olivera, Vignjevic, Sanja, Djikic, Dragoslava, Beleslin-Cokic, Bojana B, Perunicic, Maja, Ilic, Bojana, Jovcic, Gordana, Gotic, Mirjana, Noguchi, Constance Tom, Schechter, Alan N
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 18.11.2011

Abstract 3847 The microvessel density of bone marrow is increased in myeloproliferative neoplasms (MPN) parallel with vascular endothelial growth factor (VEGF). VEGF-mediated angiogenesis requires nitric oxide (NO) production from activated endothelial NO synthase (eNOS). NO as well as hypoxia stimu...