Ifnα Mediated Remodeling of the Bone Marrow Stem Cell Vascular Niche

• Published in: Blood Vol. 128; no. 22; p. 2667
• Main Authors: Prendergast, Áine M., Kuck, Andrea, van Essen, Mieke, Haas, Simon, Blaszkiewicz, Sandra, Essers, Marieke A.G.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 02.12.2016

In the bone marrow (BM), endothelial cells (ECs) are a major component of the hematopoietic stem cell (HSC) vascular niche and are a first line of defense against inflammatory stress and infection. The primary response of an organism to infection involves the synthesis of immune-modulatory cytokines...