Transcriptional and Translational Regulation of the Cancer-Testis Antigen PRAME Mediated by Pathogen-Associated Molecular Patterns

• Published in: Blood Vol. 116; no. 21; p. 2475
• Main Authors: Wadelin, Frances R, Spriggs, Keith A, Falcone, Franco H, Heery, David M
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 19.11.2010

Abstract 2475 PRAME (preferentially expressed antigen in melanoma) is a germinal tissue-specific gene that is expressed at high levels in a number of haematological malignancies. In AML, PRAME is a positive prognostic indicator, being associated with a favourable response to chemotherapy and increas...