Mannose-Binding Lectin Deficiency - a Risk Factor for Invasive Aspergillosis in Immunocompromised Patients

• Published in: Blood Vol. 112; no. 11; p. 1465
• Main Authors: Lambourne, Jonathan, Agranoff, Dan, Buchbinder, Aby, Troke, Peter F, Herbrecht, Raoul, Lindsay, Jodi, Harrison, Thomas
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 16.11.2008

Invasive aspergillosis is a devastating infection with 30–40% mortality. Immune mechanisms involved in recognition and elimination of aspergillus are incompletely understood. Mannose-binding lectin (MBL) deficiency occurs in 10–15% of the population and has been identified as a susceptibility factor...