Autologous Hematopoietic Stem Cell Transplantation for Type I Diabetes Mellitus

• Published in: Blood Vol. 104; no. 11; p. 5224
• Main Authors: Voltarelli, Julio C., Couri, Carlos E.B., Oliveira, Maria-Carolina B., Stracieri, Ana-Beatriz P.L., Moraes, Daniela A., Godoi, Dannielle F., Coutinho, Marina A., Malmegrim, Kelen C.R., Foss-Freitas, Maria-Cristina, Foss, Milton C., Simoes, Belinda P., Squiers, Elizabeth C., Burt, Richard K.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 16.11.2004

Insulin-dependent type I diabetes mellitus (IDDM) is caused by autoimmune destruction of pancreatic β-islet cells mediated by inflammatory T cells. The pathogenic process evolves gradually for several years and becomes symptomatic when most Langerhans islands are destroyed. Antibodies against β-cell...