Correlation between Antifactor Xa Activity and Thrombin Generation Time, Platelet Contractile Force and Clot Elastic Modulus Following Enoxaparin Exposure in Patients with and without Renal Dysfunction

• Published in: Blood Vol. 106; no. 11; p. 4144
• Main Authors: Brophy, Donald F., Martin, Erika J., Gehr, Todd W.B., Best, Al M., Carr, Marcus E.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 16.11.2005

Patients with renal dysfunction that receive hemodialysis (HD) are highly sensitive to low molecular weight heparin (LMWH) drugs such as Enoxaparin. There have been numerous reports of hemorrhagic effects with these drugs in this population. Although current guidelines recommend judicious monitoring...