Developing a Therapeutic Anti - Dendritic Cell Antibody to Prevent Graft Versus Host Disease

• Published in: Blood Vol. 114; no. 22; p. 3554
• Main Authors: Hart, Derek, Seldon, Therese, Jones, Martina, Sheng, Yonghua, Palkova, Anna, Cullup, Hannah, Munro, Trent, Sinfield, Laura, Rice, Alison M, Wilson, John, Gray, Peter, Barnard, Ross, Mahler, Stephen, Munster, David
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 20.11.2009

Abstract 3554 Poster Board III-491 Host and donor dendritic cells (DC) stimulate alloreactive donor T lymphocytes, and initiate GVHD. We have shown that polyclonal antibody to the DC surface activation marker human CD83 (anti hCD83), which depletes activated DC, can prevent human DC and T cell induc...