Prophylactic Nrf2 Activation Halts Progression of the Severe Adult Phenotype of Sickle Cell Disease in Transgenic Mice

• Published in: Blood Vol. 126; no. 23; p. 3394
• Main Authors: Ghosh, Samit, Ihunnah, Chibueze A., Hazra, Rimi, Owusu-Ansah, Amma T., Hansen, Jason M, Archer, David R., Ofori-Acquah, Solomon Fiifi
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 03.12.2015

Transition from pediatric to adult care is associated with poor prognosis and a sharp rise in mortality in sickle cell disease (SCD). Hitherto, mechanisms that promote the severe adult phenotype of SCD have not been defined. We performed a longitudinal cohort study in thirty-two Townes transgenic mi...