A Novel Epigenetic Mechanism in the Pathogenesis of Myelodysplastic Syndrome (MDS)

• Published in: Blood Vol. 118; no. 21; p. 2783
• Main Authors: Cheng, Jason X, Anastasi, John, Shen, Jeffery Q, Watanabe, Kenneth Q, Grimley, Edward, Kleinbrink, Erica, Knibbs, Randal, Vardiman, James W.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 18.11.2011

Abstract 2783 Refractory cytopenia with multilineage dysplasia (RCMD) is a subtype of MDS characterized by cytopenia, multilineage dysplasia, but no increase in blasts. These features suggest dysregulation in the lineage commitment of progenitors early in hematopoietic cell development. PU.1, an ETS...