A Phase 1 Study of Prasugrel in Subjects with Sickle Cell Disease: Impact on Ex Vivo Platelet Reactivity

• Published in: Blood Vol. 118; no. 21; p. 1053
• Main Authors: Jakubowski, Joseph A., Zhou, Chunmei, Small, David S., Winters, Kenneth J., Lachno, D. Richard, Frelinger, Andrew L., Howard, Jo, Jurcevic, Stipo, Payne, Christopher D.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 18.11.2011

Abstract 1053 There is evidence of increased platelet reactivity in subjects with sickle cell disease (SCD). This could contribute to vaso-occlusive complications that characterize the disease; thus, antiplatelet therapy may be useful in the management of SCD. Prasugrel, a novel thienopyridine P2Y12...