Memory B Cells Display Changes In The Expression Pattern Of Genes Related To Cell Survival In Elderly Individuals

• Published in: Blood Vol. 122; no. 21; p. 4893
• Main Authors: Baez, Alicia, Alvarez-Laderas, Isabel, Piruat, Jose Ignacio, Caballero-Velazquez, Teresa, Millan-Ucles, Africa, Barbado, María Victoria, Medrano, Mayte, Garcia-Guerrero, Estefania, Sanchez-Abarca, Luis Ignacio, Perez-Simón, Jose Antonio, Espigado, Ildefonso
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 15.11.2013

Memory B cells (MBCs) have a very long half-life, remaining viable in a quiescent state for years. However, elderly individuals have less amount of MBCs and they produce lower amounts of antibodies. Thus, in aged individuals immunization become less efficient in terms of quantity and quality. Furthe...