Identification of a Gene Expression Signature Characterizing Clonal Fitness and Dominance in Vivo in a Murine Model of MLL-AF9 Leukemia

• Published in: Blood Vol. 124; no. 21; p. 2383
• Main Authors: Mercier, Francois, Shi, Jiantao, Sykes, David, Kfoury, Youmna Sami, Yusuf, Rushdia Z., Miller, Elizabeth, Vasic, Radovan, Zhu, Alex, Michor, Franziska, Hide, Winston, Scadden, David T.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 06.12.2014

Rationale: Human malignancies are often composed of multiple, related clones that arise through a process of branching Darwinian evolution. In acute myeloid leukemia (AML), high-throughput DNA sequencing identifies clonal heterogeneity at the mutational level, but the downstream molecular pathways d...