Defining the Impact of Tandem Autologous Stem Cell Transplantation in Multiple Myeloma: A Case-Match Analysis in the Total Therapy Trials

• Published in: Blood Vol. 126; no. 23; p. 3182
• Main Authors: Thanendrarajan, Sharmilan, Stein, Caleb K., Davies, Faith E, van Rhee, Frits, Zangari, Maurizio, Heuck, Christoph, Schinke, Carolina, Waheed, Sarah, Jethava, Yogesh, Weinhold, Niels, Matin, Aasiya, Mathur, Pankaj, Mohan, Meera, Radhakrishnan, Muthukumar, Barlogie, Bart, Morgan, Gareth J
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 03.12.2015

Introduction The introduction of melphalan-based high-dose chemotherapy and autologous stem cell transplantation (MEL-ASCT) has markedly improved the survival of patients with multiple myeloma (MM). The initial clinical studies suggested conditioning with melphalan (MEL) 200 mg/m2 was optimum compar...