Hypoxia Potentiates Notch-Induced Expansion of Human Hematopoietic Stem/Progenitor Cells

• Published in: Blood Vol. 128; no. 22; p. 2640
• Main Authors: Fu, Jianfei, Huntsman, Heather D., Cash, Ayla, Cheruku, Patali S., Smith, Richard H., Liang, Aibin, Bernstein, Irwin D., Larochelle, Andre
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 02.12.2016

Activation of Notch signaling in human hematopoietic stem/progenitor cells (HSPCs) by treatment with Notch ligand Delta1 has enabled a clinically relevant ex vivo expansion of short-term HSPCs. In vitro studies have also revealed a role of low O2 tension in HSPC regulation. A molecular link has been...