Efficient Engraftment and Disease Replication of Myelodysplastic Syndromes Using a Novel Humanized Mice Model

• Published in: Blood Vol. 126; no. 23; p. 4100
• Main Authors: Song, Yuanbin, Taylor, Ashley, Rongvaux, Anthony, Jiang, Tingting, Podoltsev, Nikolai A., Xu, Mina, Neparidze, Natalia, Torres, Richard, Barbarotta, Lisa M, Balasubramanian, Kunthavai, Finberg, Karin E, Kluger, Yuval, Flavell, Richard, Halene, Stephanie
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 03.12.2015

Myelodysplastic Syndromes (MDS) are a heterogeneous disorder of the hematopoietic stem cell caused by a large number of genetic and epigenetic alterations. With the development of novel therapeutics a reliable model to test the drugs' efficacy in correlation with genetic and epigenetic alterati...