Activation of Endogenous H 2 S Biosynthesis or Supplementation with Exogenous H 2 S Enhances Adipose Tissue Adipogenesis and Preserves Adipocyte Physiology in Humans

• Published in: Antioxidants & redox signaling Vol. 35; no. 5; p. 319
• Main Authors: Comas, Ferran, Latorre, Jèssica, Ortega, Francisco, Arnoriaga Rodríguez, María, Kern, Matthias, Lluch, Aina, Ricart, Wifredo, Blüher, Matthias, Gotor, Cecilia, Romero, Luis C, Fernández-Real, José Manuel, Moreno-Navarrete, José María
• Format: Journal Article
• Language: English
• Published: United States 10.08.2021
• Subjects: Adipocytes - drug effects; Adipocytes - metabolism; Adipogenesis - drug effects; Adipose Tissue - drug effects; Adipose Tissue - metabolism; Cross-Sectional Studies; Dietary Supplements; Humans; Hydrogen Sulfide - administration & dosage; Hydrogen Sulfide - pharmacology; Obesity, Morbid - drug therapy; Obesity, Morbid - metabolism; adipose tissue; adipogenesis; protein persulfidation; hydrogen sulfide; obesity

To investigate the impact of exogenous hydrogen sulfide (H S) and its endogenous biosynthesis on human adipocytes and adipose tissue in the context of obesity and insulin resistance. Experiments in human adipose tissue explants and in isolated preadipocytes demonstrated that exogenous H S or the act...