Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMME n SE consortium

Abstract Genome‐wide association studies ( GWAS ) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, even though it is devoid of genes. Given that no GWAS data are currently available for multiple myeloma ( MM ), we tested the hypothesis that genetic variants i...

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Published inBritish journal of haematology Vol. 157; no. 3; pp. 331 - 338
Main Authors Campa, Daniele, Martino, Alessandro, Sainz, Juan, Buda, Gabriele, Jamroziak, Krzysztof, Weinhold, Niels, Reis, Rui Manuel Vieira, García‐Sanz, Ramón, Jurado, Manuel, Ríos, Rafael, Szemraj‐Rogucka, Zofia, Marques, Herlander, Lesueur, Fabienne, Bugert, Peter, Moreno, Victor, Szemraj, Janusz, Orciuolo, Enrico, Gemignani, Federica, Rossi, Anna Maria, Dumontet, Charles, Petrini, Mario, Goldschmidt, Hartmut, Landi, Stefano, Canzian, Federico
Format Journal Article
LanguageEnglish
Published 01.05.2012
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Abstract Abstract Genome‐wide association studies ( GWAS ) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, even though it is devoid of genes. Given that no GWAS data are currently available for multiple myeloma ( MM ), we tested the hypothesis that genetic variants in this region could play a role in MM risk. We genotyped 20 single nucleotide polymorphisms of 8q24 in 1188 MM cases and 2465 controls and found a statistically significant ( P  = 0·0022) association between rs2456449 and MM risk. These data provide further evidence that the genetic variability in the 8q24 region is associated with cancer risk, particularly haematological malignancies.
AbstractList Abstract Genome‐wide association studies ( GWAS ) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, even though it is devoid of genes. Given that no GWAS data are currently available for multiple myeloma ( MM ), we tested the hypothesis that genetic variants in this region could play a role in MM risk. We genotyped 20 single nucleotide polymorphisms of 8q24 in 1188 MM cases and 2465 controls and found a statistically significant ( P  = 0·0022) association between rs2456449 and MM risk. These data provide further evidence that the genetic variability in the 8q24 region is associated with cancer risk, particularly haematological malignancies.
Author Ríos, Rafael
Canzian, Federico
Jamroziak, Krzysztof
Weinhold, Niels
Landi, Stefano
García‐Sanz, Ramón
Goldschmidt, Hartmut
Reis, Rui Manuel Vieira
Szemraj‐Rogucka, Zofia
Lesueur, Fabienne
Martino, Alessandro
Petrini, Mario
Buda, Gabriele
Sainz, Juan
Jurado, Manuel
Dumontet, Charles
Gemignani, Federica
Moreno, Victor
Orciuolo, Enrico
Szemraj, Janusz
Campa, Daniele
Marques, Herlander
Bugert, Peter
Rossi, Anna Maria
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  surname: Campa
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  organization: Genomic Oncology Area GENYO – (Pfizer‐University of Granada‐Andalusian Government Center for Genomics and Oncological Research) Granada Spain, Department of Haematology Virgen de las Nieves University Hospital Granada Spain
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  organization: Genetic Cancer Susceptibility Group International Agency for Research on Cancer IARC Lyon France
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  organization: Medical Faculty Mannheim German Red Cross Blood Service Baden‐Württemberg – Hessen Institute of Transfusion Medicine and Immunology Heidelberg University Mannheim Germany
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  givenname: Victor
  surname: Moreno
  fullname: Moreno, Victor
  organization: IDIBELL – Catalan Institute of Oncology CIBERESP and University of Barcelona Barcelona Spain
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Title Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMME n SE consortium
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