RTA 1701 is an oral RORγt inhibitor that suppresses the IL-17A response in non-human primates

• Published in: The Journal of immunology (1950) Vol. 200; no. 1_Supplement; pp. 175 - 175.22
• Main Authors: Reisman, Scott A., Lee, Chun-Yue I., Proksch, Joel W., Sakamoto, Mitsumasa, Ward, Keith W.
• Format: Journal Article
• Language: English
• Published: 01.05.2018

Abstract RTA 1701 is an orally-bioavailable, selective RORγt inhibitor. RORγt orchestrates the differentiation of Th17 cells and contributes to autoimmune disease pathogenesis. Inhibition of RORγt suppresses Th17 cells and the associated secretion of the effector pro-inflammatory cytokine IL-17A. As...