FK506 BINDING PROTEIN 8 (FKBP8) INTERACTIONS WITH MYOSIN LIGHT CHAIN KINASE 1 ARE REQUIRED FOR TNF-INDUCED TIGHT JUNCTION BARRIER LOSS

• Published in: Inflammatory bowel diseases Vol. 27; no. Supplement_1; p. S25
• Main Authors: Zuo, Li, Cao, Feng, Kuo, Wei-Ting, Turner, Jerrold
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 21.01.2021
• Subjects: Kinases; Permeability; Phosphorylation; Proteins; Tumor necrosis factor-TNF

Abstract Background Tumor necrosis factor (TNF) regulates intestinal epithelial tight junction permeability by activating myosin light chain kinase 1 (MLCK1) expression and enzymatic activity. MLCK1 recruitment to the apical perijunctional actomyosin ring (PAMR) is, however, required for barrier reg...