Pharmacological and genetic approaches to downregulate FIS1 mitigate neuropathic pain

• Published in: The Journal of neuroscience Vol. 45; no. 35; p. e0523252025
• Main Authors: Zhu, Chang-Lei, Li, Shu-Jiao, Lin, Zhi-Peng, Ni, Zi-Wei, Tian, Ke, Xia, Yu-Lu, Tie, Jing-Jing, Pu, Xue-Yin, Huang, Yun-Qiang, Wu, Fei-Fei, Liu, Hui, Zhang, Kun-Long, Zhang, Shuai, Wu, You-Sheng, Tian, Fei, Liu, Nan-Nan, Ruan, Cai-Lian, Yang, Yan-Ling, Wang, Ya-Yun
• Format: Journal Article
• Language: English
• Published: United States 06.08.2025
• Subjects: Animals; Down-Regulation - drug effects; Hyperalgesia - drug therapy; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondrial Proteins - biosynthesis; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Neuralgia - drug therapy; Neuralgia - genetics; Neuralgia - metabolism; Spinal Cord Dorsal Horn - drug effects; Spinal Cord Dorsal Horn - metabolism; Vesicular Glutamate Transport Protein 2 - genetics; mitochondrial fragmentation; neuropathic pain; mitochondrial fission protein 1; spinal cord dorsal horn

Despite the established link between neuropathic pain and abnormal mitochondrial fission in neurons, the specific role of mitochondrial fission protein 1 (FIS1) in this process remains to be fully elucidated. In this study, the subjects we investigated were 6-8-week-old male mice. Comprehensive beha...