5‐HT 6 receptor binding sites in schizophrenia and following antipsychotic drug administration: Autoradiographic studies with [ 125 I]SB‐258585

• Published in: Synapse (New York, N.Y.) Vol. 45; no. 3; pp. 191 - 199
• Main Authors: East, Simon Z., Burnet, Philip W.J., Leslie, Ronald A., Roberts, Jennifer C., Harrison, Paul J.
• Format: Journal Article
• Language: English
• Published: 01.09.2002

Abstract The 5‐hydroxytryptamine (5‐HT; serotonin)‐6 receptor (5‐HT 6 R) is a putative target of atypical antipsychotic drugs and its mRNA expression is altered in schizophrenia. [ 125 I]SB‐258585 is a selective 5‐HT 6 R antagonist which has been well characterized for use in the rat brain. The pres...