Impaired Online and Enhanced Offline Motor Sequence Learning in Individuals with Parkinson's Disease

• Published in: The Journal of neuroscience Vol. 45; no. 35; p. e2193242025
• Main Authors: Van Roy, Anke, Dan, Xiaojuan, Micca, Letizia, Gilat, Moran, Chan, Piu, Doyon, Julien, Albouy, Genevieve, King, Bradley R.
• Format: Journal Article
• Language: English
• Published: United States 27.08.2025
• Subjects: Aged; Female; Humans; Learning - physiology; Learning Disabilities - etiology; Male; Middle Aged; Parkinson Disease - complications; Parkinson Disease - physiopathology; Parkinson Disease - psychology; Psychomotor Performance - physiology; Serial Learning - physiology; Parkinson's disease; hippocampus; motor learning; striatum; consolidation

Whereas memory consolidation research has traditionally focused on longer temporal windows (i.e., hours to days) following an initial learning episode, recent research has also examined the functional significance of the shorter rest epochs interspersed with blocks of task practice (i.e., “micro-off...