Gene expression profiling of oxidative and anti‐oxidative genes in keratoconus patients

• Published in: Acta ophthalmologica (Oxford, England) Vol. 103; no. S284
• Main Authors: Sharma, Shivam, Singh, Lata, Kashyap, Seema, Sen, Seema, Sharma, Namrata
• Format: Journal Article
• Language: English
• Published: Malden Wiley Subscription Services, Inc 01.01.2025
• Subjects: Age; Cornea; Down-regulation; Gene expression; Keratoconus; NOX4 protein; Oxidative stress; Stroma; Superoxide dismutase; Up-regulation

Aims/Purpose: Keratoconus (KC) is thinning of corneal stroma & irregular astigmatism, resulting in diminution of vision. Despite its prevalence, the underlying etiology is poorly understood. Emerging evidence suggests a dysregulation of oxidative balance and mitochondrial function in KC corneas....