Abstract 4142546: Single-Nucleus RNA Sequencing Reveals Region-Specific Cell Composition and Transcriptional Variations in Cardiac Sarcoidosis

• Published in: Circulation (New York, N.Y.) Vol. 150; no. Suppl_1; p. A4142546
• Main Authors: Neyazi, Meraj, Kim, Yuri, Brown, Kemar, Barish, Syndi, Gorham, Joshua, Layton, Olivia, Viveiros, Anissa, DeLaughter, Daniel, Beyer, Martin, Strohmenger, Viktoria, Reichart, Daniel, Bowles, Dawn, Glass, Carolyn, Oudit, Gavin, Seidman, Jonathan, Seidman, Christine
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 12.11.2024
• Subjects: Genetics; Autoimmune; Sarcoidosis; Transcriptomics; Biomedical informatics

Introduction: Sarcoidosis is a granulomatous disease of unknown cause that can affect any organ. Cardiac involvement, indicated by arrhythmias, conduction abnormalities, heart failure, and sudden cardiac death, occurs in about 5% of cases and accounts for 50% of sarcoid-related deaths. Yet, autopsy...